Memory and relatedness of transcriptional activity in mammalian cell lineages

Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial pat...

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Bibliographic Details
Main Authors: Nicholas E. Phillips, Aleksandra Mandic, Saeed Omidi, Felix Naef, David M. Suter
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09189-8