Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response...

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Bibliographic Details
Main Authors: Brian W. LeBlanc, Brent Cross, Kelsey A. Smith, Catherine Roach, Jimmy Xia, Yu-Chieh Chao, Joshua Levitt, Suguru Koyama, Christopher I. Moore, Carl Y. Saab
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02753-6