Unusual Regioselectivity in the Opening of Epoxides by Carboxylic Acid Enediolates

Unusual Regioselectivity in the Opening of Epoxides by Carboxylic Acid Enediolates

Addition of carboxylic acid dianions appears to be a potential alternative to the use of aluminium enolates for nucleophilic ring opening of epoxides. These conditions require the use of a sub-stoichiometric amount of amine (10% mol) for dianion generation and the previous activation of the epoxide...

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Bibliographic Details
Main Authors: José Segura, Margarita Parra, Salvador Gil, Luis R. Domingo
Format: Article
Language:English
Published: MDPI AG 2008-06-01
Series:Molecules
Subjects:
Lactones
lithium chloride
nucleophilic addition
regioselectivity
diastereoselectivity.
Online Access:http://www.mdpi.com/1420-3049/13/6/1303/

Internet

http://www.mdpi.com/1420-3049/13/6/1303/

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