A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors

A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors

Protein ubiquitinations play pivotal roles in many cellular processes, including homeostasis, responses to various stimulations, and progression of diseases. Deubiquitinating enzymes (DUBs) remove ubiquitin molecules from ubiquitinated proteins and cleave the polyubiquitin chain, thus negatively reg...

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Bibliographic Details
Main Authors: Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomedicines
Subjects:
deubiquitinating enzyme
polyubiquitin chain linkage
DUB inhibitor
wheat cell-free system
protein array technology
Online Access:https://www.mdpi.com/2227-9059/8/6/152

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https://www.mdpi.com/2227-9059/8/6/152

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