Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD

Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 gene (C9ORF72). This hexanucleotide expansion consists of GGGGCC (G4C2) repeats that have been implicated to lead to three ma...

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Bibliographic Details
Main Authors: Alexander Schmitz, João Pinheiro Marques, Irina Oertig, Niran Maharjan, Smita Saxena
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral scelerosis
C9ORF72 ALS/FTD
dipeptide repeat proteins (DPRs)
RAN translation
neurodegeneration
motor neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.637548/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.637548/full

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