The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new urinary biomarkers are needed to monitor this...

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Bibliographic Details
Main Authors: Aiping Zhang, Kitipong Uaesoontrachoon, Conner Shaughnessy, Jharna R. Das, Sree Rayavarapu, Kristy J. Brown, Patricio E. Ray, Kanneboyina Nagaraju, John N. van den Anker, Eric P. Hoffman, Yetrib Hathout
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
PMO
Urinary biomarkers
mdx-23
Duchenne muscular dystrophy
Clusterin
GGT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015300019

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http://www.sciencedirect.com/science/article/pii/S2214750015300019

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