Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors

Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors

Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has been identified in proliferative nestin-positive adult neural progenitor cells a...

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Bibliographic Details
Main Authors: Ana Cicvaric, Hannah M. Sachernegg, Tamara Stojanovic, Dörte Symmank, Tarik Smani, Thomas Moeslinger, Pavel Uhrin, Francisco J. Monje
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurogenesis
podoplanin
LTD
anxiety-like behavior
NGF
cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00561/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00561/full

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