Crystal structure of Cryptosporidium parvum pyruvate kinase.

Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars. In response to binding of effector molecules and substrates, significant st...

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Bibliographic Details
Main Authors: William J Cook, Olga Senkovich, Khadijah Aleem, Debasish Chattopadhyay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3467265?pdf=render