Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of helices αA, αB, and αC. Here, we report the biochem...

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Bibliographic Details
Main Authors: Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
flavoprotein
proline dehydrogenase
protein engineering
protein oligomerization
solubility tag
suicide inhibition
TIM-barrel
Online Access:http://www.mdpi.com/1420-3049/23/1/184

Internet

http://www.mdpi.com/1420-3049/23/1/184

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