Quantitative proteomics and transcriptomics reveals metabolic differences in attracting and non-attracting human-in-mouse glioma stem cell xenografts and stromal cells

Quantitative proteomics and transcriptomics reveals metabolic differences in attracting and non-attracting human-in-mouse glioma stem cell xenografts and stromal cells

Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) show promise as cell-based delivery vehicles for anti-glioma therapeutics, due to innate tropism for gliomas. However, in clinically relevant human-in-mouse glioma stem cell xenograft models, BM-hMSCs tropism is variable. We compared the pr...

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Bibliographic Details
Main Authors: Norelle C. Wildburger, Cheryl F. Lichti, Richard D. LeDuc, Mary Schmidt, Roger A. Kroes, Joseph R. Moskal, Carol L. Nilsson
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:EuPA Open Proteomics
Subjects:
Glioblastoma
Bone marrow-derived human mesenchymal stem cells (BM-hMSCs)
Mass spectrometry
Cancer proteomics
Transcriptomics
Fatty acid metabolism
Glycolysis
Pentose phosphate pathway
ROS
Glycosylation
Online Access:http://www.sciencedirect.com/science/article/pii/S221296851530009X

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http://www.sciencedirect.com/science/article/pii/S221296851530009X

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