Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells

Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells

Abstract Background Senescent cells exert a significant influence over their surrounding cellular environment. Senescent chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present in joints affected by osteoarthritis. The influence of SnChos on exogenously transplanted stem...

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Bibliographic Details
Main Authors: Xu Cao, Pan Luo, Junjie Huang, Chi Liang, Jinshen He, Zili Wang, Dongyong Shan, Cheng Peng, Song Wu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Senescent chondrocytes (SnChos)
Bone marrow mesenchymal stem cells (BMSCs)
Intra-articular senescent microenvironment (IASM)
Osteoarthritis (OA)
Cartilage repair
Online Access:http://link.springer.com/article/10.1186/s13287-019-1193-1

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http://link.springer.com/article/10.1186/s13287-019-1193-1

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