The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

Abstract Background Most eukaryotic genes are subject to alternative splicing (AS), which may contribute to the production of protein variants or to the regulation of gene expression via nonsense-mediated messenger RNA (mRNA) decay (NMD). However, a fraction of splice variants might correspond to sp...

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Bibliographic Details
Main Authors: Baptiste Saudemont, Alexandra Popa, Joanna L. Parmley, Vincent Rocher, Corinne Blugeon, Anamaria Necsulea, Eric Meyer, Laurent Duret
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Genome Biology
Subjects:
Alternative splicing
Random genetic drift
Selectionist/neutralist debate
Online Access:http://link.springer.com/article/10.1186/s13059-017-1344-6

Internet

http://link.springer.com/article/10.1186/s13059-017-1344-6

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