Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice.

Animal models are vital to the study of transfusion and development of new blood products. Post-transfusion recovery of human blood components can be studied in mice, however, there is a need to identify strains that can best tolerate xenogeneic transfusions, as well as to optimize such protocols. S...

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Bibliographic Details
Main Authors: Sophia A Blessinger, Johnson Q Tran, Rachael P Jackman, Renata Gilfanova, Jacqueline Rittenhouse, Alan G Gutierrez, John W Heitman, Kelsey Hazegh, Tamir Kanias, Marcus O Muench
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237106