Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors

Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors

Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosar...

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Bibliographic Details
Main Authors: Michael V. Ortiz, Stephen S. Roberts, Julia Glade Bender, Neerav Shukla, Leonard H. Wexler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
glypican 3
hepatoblastoma (HB)
germ cell tumors (GCT)
Wilms tumor (WT)
rhabdoid tumor
rhabdomyosarcoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00108/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00108/full

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