Treatment of Intestinal Inflammation With Epicutaneous Immunotherapy Requires TGF-β and IL-10 but Not Foxp3+ Tregs

Background: Inflammatory bowel disease (IBD) involves an increase in T effector cells in the intestines that disrupts the normal balance with T regulatory cells (Tregs). A therapy that restores this balance has the potential to treat IBD. We have shown that epicutaneous exposure to OVA induces Tregs...

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Bibliographic Details
Main Authors: Xin Chen, M. Cecilia Berin, Virginia L. Gillespie, Hugh A. Sampson, David Dunkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
IBD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637630/full