Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
The unfolded protein response (UPR) is an adaptive signaling pathway utilized to sense and alleviate the stress of protein folding in the endoplasmic reticulum (ER). In mammals, the UPR is mediated through three proximal sensors PERK/PEK, IRE1, and ATF6. PERK/PEK is a protein kinase that phosphoryla...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-09-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1231716?pdf=render |