A toll-like receptor 9 antagonist reduces pain hypersensitivity and the inflammatory response in spinal cord injury

A toll-like receptor 9 antagonist reduces pain hypersensitivity and the inflammatory response in spinal cord injury

Toll-like receptors (TLRs) are mediators of the innate immune response to exogenous pathogens. They have also been implicated in sterile inflammation associated with systemic injury and non-infectious diseases via binding of endogenous ligands, possibly released by damaged cells. Emerging evidence i...

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Bibliographic Details
Main Authors: Brian T. David, Ayomi Ratnayake, Matthew A. Amarante, Naresh Parvath Reddy, Wei Dong, Sujitha Sampath, Robert F. Heary, Stella Elkabes
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
CpG ODN
TLR
Allodynia
Innate immunity
Cytokine
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611300003X

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http://www.sciencedirect.com/science/article/pii/S096999611300003X

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