Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...

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Bibliographic Details
Main Authors: Chean Hui Ng, Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Faridah Abas, Kok Wai Lam, Intan Safinar Ismail, Radhakrishnan Narayanaswamy, Fadzureena Jamaludin, Khozirah Shaari
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
lipoxygenase
analogs
Friedel-Craft acylation
Friedel-Craft alkylation
molecular docking
Online Access:http://www.mdpi.com/1420-3049/19/8/11645

Internet

http://www.mdpi.com/1420-3049/19/8/11645

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