FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.

Gene transcription is constrained by the nucleosomal nature of chromosomal DNA. This nucleosomal barrier is modulated by FACT, a conserved histone-binding heterodimer. FACT mediates transcription-linked nucleosome disassembly and also nucleosome reassembly in the wake of the RNA polymerase II transc...

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Bibliographic Details
Main Authors: Jennifer R Stevens, Allyson F O'Donnell, Troy E Perry, Jeremy J R Benjamin, Christine A Barnes, Gerald C Johnston, Richard A Singer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192111?pdf=render

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http://europepmc.org/articles/PMC3192111?pdf=render

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