Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease

Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease

Chorea-acanthocytosis (ChAc) is a neurodegenerative disease caused by mutations in the <i>VPS13A</i> gene. It is characterized by several neurological symptoms and the appearance of acanthocytes. Elevated tyrosine kinase Lyn activity has been recently identified as one of the key pathoph...

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Bibliographic Details
Main Authors: Kevin Peikert, Hannes Glaß, Enrica Federti, Alessandro Matte, Lisann Pelzl, Katja Akgün, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, The Network for Translational Research for Neuroacanthocytosis Patients, Lucia De Franceschi, Andreas Hermann
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Personalized Medicine
Subjects:
ChAc
neuroacanthocytosis
off-label
dasatinib
TKI
Online Access:https://www.mdpi.com/2075-4426/11/5/392

Internet

https://www.mdpi.com/2075-4426/11/5/392

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