Combination strategies to overcome resistance to the BCL2 inhibitor venetoclax in hematologic malignancies

Abstract Venetoclax has been approved by the United States Food and Drug Administration since 2016 as a monotherapy for treating patients with relapsed/refractory chronic lymphocytic leukemia having 17p deletion. It has led to a breakthrough in the treatment of hematologic malignancies in recent yea...

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Bibliographic Details
Main Authors: XiaoYan Yue, Qingxiao Chen, JingSong He
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-020-01614-z