QSAR Implementation for HIC Retention Time Prediction of mAbs Using Fab Structure: A Comparison between Structural Representations

QSAR Implementation for HIC Retention Time Prediction of mAbs Using Fab Structure: A Comparison between Structural Representations

Monoclonal antibodies (mAbs) constitute a rapidly growing biopharmaceutical sector. However, their growth is impeded by high failure rates originating from failed clinical trials and developability issues in process development. There is, therefore, a growing need for better in silico tools to aid i...

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Bibliographic Details
Main Authors: Micael Karlberg, João Victor de Souza, Lanyu Fan, Arathi Kizhedath, Agnieszka K. Bronowska, Jarka Glassey
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
monoclonal antibodies
quantitative structure–activity relationship
hydrophobic interaction chromatography
process development
manufacturability
protein dynamics analysis
Online Access:https://www.mdpi.com/1422-0067/21/21/8037

Internet

https://www.mdpi.com/1422-0067/21/21/8037

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