C-C chemokine receptor-7 mediated endocytosis of antibody cargoes into intact cells

C-C chemokine receptor-7 mediated endocytosis of antibody cargoes into intact cells

The C-C chemokine receptor-7 (CCR7) is a G protein coupled receptor that has a role in leukocyte homing, but that is also expressed in aggressive tumor cells. Preclinical research supports that CCR7 is a valid target in oncology. In view of the increasing availability of therapeutic monoclonal antib...

Full description

Bibliographic Details
Main Authors: Xavier eCharest-Morin, Rémy ePépin, Angélique eGagné-Henley, Guillaume eMorissette, Robert eLodge, François eMarceau
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Pharmacology
Subjects:
Melanoma
CCR7
CCL19
β-arrestin
Rab5
Rab7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00122/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00122/full

Similar Items