Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

Lochocki et al. report detection of amyloid plaques by label-free fluorescence and Raman imaging in snap-frozen frontal cortex tissue from Alzheimer’s disease cases. They identify presence of carotenoid in a cored amyloid plaque area, versus a non-plaque area, suggesting a distinct neuroinflammatory...

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Bibliographic Details
Main Authors: Benjamin Lochocki, Baayla D. C. Boon, Sander R. Verheul, Liron Zada, Jeroen J. M. Hoozemans, Freek Ariese, Johannes F. de Boer
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01981-x