Phenobarbital but not diazepam reduces AMPA/Kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus

Phenobarbital but not diazepam reduces AMPA/Kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus

Diazepam (DZP) and phenobarbital (PB) are extensively used as first and second line drugs to treat acute seizures in neonates and their actions are thought to be mediated by increasing the actions of GABAergic signals. Yet, their efficacy is variable with occasional failure or even aggravation of re...

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Bibliographic Details
Main Authors: Romain eNardou, Sumii eYamamoto, Asma eBhar, Nael eBurnashev, Yehezkel eBen-Ari, Ilgam eKhalilov
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Diazepam
Phenobarbital
Seizures
AMPA
immature hippocampus
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00016/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00016/full

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