Up-regulation of COX-2/PGE<sub>2</sub> by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells

Up-regulation of COX-2/PGE<sub>2</sub> by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells

<p>Abstract</p> <p>Background</p> <p>Endothelin-1 (ET-1) is a proinflammatory mediator and elevated in the regions of several brain injury and inflammatory diseases. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through t...

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Bibliographic Details
Main Authors: Lin Chih-Chung, Hsieh Hsi-Lung, Shih Ruey-Horng, Chi Pei-Ling, Cheng Shin-Ei, Yang Chuen-Mao
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Cell Communication and Signaling
Subjects:
Endothelin-1
COX-2
MAPK
NF-κB
Brain microvascular endothelial cells
Online Access:http://www.biosignaling.com/content/11/1/8

Internet

http://www.biosignaling.com/content/11/1/8

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