Increased global transcription activity as a mechanism of replication stress in cancer

Increased global transcription activity as a mechanism of replication stress in cancer

Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.

Bibliographic Details
Main Authors: Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M. Jones, Lisa Folkes, Natalia Gromak, Eva Petermann
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13087

Internet

https://doi.org/10.1038/ncomms13087

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