Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death

Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective loss of motor neurons. Stress activated protein kinases (SAPK) have been suggested to play a role in the pathogenesis of ALS. We studied the relevance of p38 MAPK for motor neuron degeneration in the m...

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Bibliographic Details
Main Authors: Maarten Dewil, Vidal F. dela Cruz, Ludo Van Den Bosch, Wim Robberecht
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neurobiology of Disease
Subjects:
ALS
Inflammation
Glia
Microglia
Motoneuron
p38 MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000034

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