GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission factors Drp1 and Fis1. Unlike other mitochondrial fission f...

Full description

Bibliographic Details
Main Authors: Axel Niemann, Konstanze Marion Wagner, Marcel Ruegg, Ueli Suter
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neurobiology of Disease
Subjects:
Apoptosis
Charcot–Marie–Tooth
Mitochondria
Neurodegeneration
Peripheral nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002526

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109002526

Similar Items