Bioinspired Syntheses of Dimeric Hydroxycinnamic Acids (Lignans) and Hybrids, Using Phenol Oxidative Coupling as Key Reaction, and Medicinal Significance Thereof

Bioinspired Syntheses of Dimeric Hydroxycinnamic Acids (Lignans) and Hybrids, Using Phenol Oxidative Coupling as Key Reaction, and Medicinal Significance Thereof

Lignans are mainly dimers of 4-hydroxycinnamic acids (HCAs) and reduced analogs thereof which are produced in Nature through phenol oxidative coupling (POC) as the primary C-C or C-O bond-forming reaction under the action of the enzymes peroxidases and laccases. They present a large structural varie...

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Bibliographic Details
Main Authors: George E. Magoulas, Dionissios Papaioannou
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
4-hydroxycinnamic acids
lignans
biomimetic synthesis
phenol oxidative coupling
regioselective coupling
stereoselective coupling
dilactones
dihydronaphthalenes
dihydrobenzofurans
hybrids
Online Access:http://www.mdpi.com/1420-3049/19/12/19769

Internet

http://www.mdpi.com/1420-3049/19/12/19769

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