NDRG2 Sensitizes Myeloid Leukemia to Arsenic Trioxide via GSK3β–NDRG2–PP2A Complex Formation

NDRG2 Sensitizes Myeloid Leukemia to Arsenic Trioxide via GSK3β–NDRG2–PP2A Complex Formation

N-Myc downstream-regulated gene 2 (NDRG2) was characterized as a tumor suppressor, inducing anti-metastatic and anti-proliferative effects in several tumor cells. However, NDRG2 functions on anticancer drug sensitivity, and its molecular mechanisms are yet to be fully investigated. In this study, we...

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Bibliographic Details
Main Authors: Soojong Park, Hyun-Tak Han, Sang-Seok Oh, Dong Hyeok Kim, Jin-Woo Jeong, Ki Won Lee, Minju Kim, Jong Seok Lim, Yong Yeon Cho, Cheol Hwangbo, Jiyun Yoo, Kwang Dong Kim
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
PP2A–NDRG2–GSK3β complex
myeloid leukemia
U937
Mcl-1
apoptosis
arsenic trioxide
Online Access:https://www.mdpi.com/2073-4409/8/5/495

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https://www.mdpi.com/2073-4409/8/5/495

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