The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours

The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours

Abstract Background The bidirectional communication between neurons and microglia is fundamental for the homeostasis and biological function of the central nervous system. Maternal immune activation (MIA) is considered to be one of the factors affecting these interactions. Accordingly, MIA has been...

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Bibliographic Details
Main Authors: Katarzyna Chamera, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Ewa Trojan, Alicja Skórkowska, Bartosz Pomierny, Weronika Krzyżanowska, Natalia Bryniarska, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Maternal immune activation
Lipopolysaccharide
Polyinosinic:polycytidylic acid
CX3CL1-CX3CR1
CD200-CD200R
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01923-0

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http://link.springer.com/article/10.1186/s12974-020-01923-0

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