Characterization of the mechanism of protection mediated by CS-D7, a monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB)

Characterization of the mechanism of protection mediated by CS-D7, a monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB)

We previously reported the development of a human monoclonal antibody (CS-D7, IgG1) with specificity and affinity for the iron regulated surface determinant B (IsdB) of Staphylococcus aureus. CS-D7 mediates opsonophagocytic killing in vitro and protection in a murine sepsis model. In light of rece...

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Bibliographic Details
Main Authors: Gregory ePancari, Hongxia eFan, Sharon eSmith, Amita eJoshi, Robin eHaimbach, Desmond eClark, Yingzhe eLi, Jin eHua, Troy eMcKelvey, Yangsi eOu, James eDrummond, Leslie eCope, Donna eMontgomery, Tessie eMcNeely
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus aureus
Vaccination
iron regulated surface determinant B (IsdB)
opsonophagocytosis
passive immunization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00036/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00036/full

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