The Past, Present, and Future of Human Centromere Genomics

The centromere is the chromosomal locus essential for chromosome inheritance and genome stability. Human centromeres are located at repetitive alpha satellite DNA arrays that compose approximately 5% of the genome. Contiguous alpha satellite DNA sequence is absent from the assembled reference genome...

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Bibliographic Details
Main Authors: Megan E. Aldrup-MacDonald, Beth A. Sullivan
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Genes
Subjects:
Online Access:http://www.mdpi.com/2073-4425/5/1/33