Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immun...

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Bibliographic Details
Main Authors: Paul S. Backhaus, Rūta Veinalde, Laura Hartmann, Jessica E. Dunder, Lara M. Jeworowski, Jessica Albert, Birgit Hoyler, Tanja Poth, Dirk Jäger, Guy Ungerechts, Christine E. Engeland
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Viruses
Subjects:
cancer immunotherapy
oncolytic virus
measles virus
interleukin-12
interleukin-15
Online Access:https://www.mdpi.com/1999-4915/11/10/914

Internet

https://www.mdpi.com/1999-4915/11/10/914

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