Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells

Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells

Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, although improving in vitro thermo-stability and in...

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Bibliographic Details
Main Authors: Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W. Landry, Mauro Magnani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
cocaine use disorder
cocaine esterase
red blood cells as drug delivery system
cocaine degradation
RBP 8000 stability
E196-301 stability
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.573492/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.573492/full

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