Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the powder or the solution. The amorphous COLI powder...

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Bibliographic Details
Main Authors: Frédéric Tewes, Julien Brillault, Nicolas Gregoire, Jean-Christophe Olivier, Isabelle Lamarche, Christophe Adier, Anne-Marie Healy, Sandrine Marchand
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
colistin dry powder inhalation
pulmonary infections
nebulization
pharmacokinetics modeling
Calu-3 permeability
Online Access:https://www.mdpi.com/1999-4923/12/6/557

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https://www.mdpi.com/1999-4923/12/6/557

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