Inhibition of IL-1β by Aliskiren Improved Renal AQP2 Expression and Urinary Concentration Defect in Ureteral Obstruction and Release

Inhibition of IL-1β by Aliskiren Improved Renal AQP2 Expression and Urinary Concentration Defect in Ureteral Obstruction and Release

We previously demonstrated that ureteral obstruction is associated with a urinary concentrating defect and reduced expression of renal aquaporins (AQPs), in which the renin–angiotensin system (RAS) may play an important role. The aims of the present study were to examine whether the renin inhibitor...

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Bibliographic Details
Main Authors: Shan Hu, Haixia Xie, Renfei Luo, Pinning Feng, Qiaojuan Liu, Mengke Han, Yonglun Kong, Xuenong Zou, Weidong Wang, Chunling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
renin inhibition
urinary concentration
ureteral obstruction
IL-1β
AQP
inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01157/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01157/full

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