Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.

Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.

Cellular metabolism plays a critical role in regulating T cell responses and the development of memory T cells with long-term protections. However, the metabolic phenotype of antigen-activated T cells that are responsible for the generation of long-lived memory cells has not been characterized.Using...

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Bibliographic Details
Main Authors: Shan He, Koji Kato, Jiu Jiang, Daniel R Wahl, Shin Mineishi, Erin M Fisher, Donna M Murasko, Gary D Glick, Yi Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3096660?pdf=render

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http://europepmc.org/articles/PMC3096660?pdf=render

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