BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development

BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development

Migration of skeletal muscle precursor cells is a key step during limb muscle development and depends on the activity of PAX3 and MET. Here, we demonstrate that BRAF serves a crucial function in formation of limb skeletal muscles during mouse embryogenesis downstream of MET and acts as a potent indu...

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Bibliographic Details
Main Authors: Jaeyoung Shin, Shuichi Watanabe, Soraya Hoelper, Marcus Krüger, Sawa Kostin, Jochen Pöling, Thomas Kubin, Thomas Braun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
Skeletal muscle development
cell migration
endosomal trafficking
intracellular signaling
B-Raf
Pax3
Online Access:https://elifesciences.org/articles/18351

Internet

https://elifesciences.org/articles/18351

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