Cholesterol Removal from Adult Skeletal Muscle impairs Excitation-Contraction Coupling and Aging reduces Caveolin-3 and alters the Expression of other Triadic Proteins

Cholesterol Removal from Adult Skeletal Muscle impairs Excitation-Contraction Coupling and Aging reduces Caveolin-3 and alters the Expression of other Triadic Proteins

Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express the caveolin-3 isoform but its association with transverse tubules remains cont...

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Bibliographic Details
Main Authors: Genaro eBarrientos, Paola eLlanos, Jorge eHidalgo, Pura eBolaños, Carlo eCaputo, Alexander eRiquelme, Gina eSanchez, Andrew F Quest, Cecilia eHidalgo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Physiology
Subjects:
NADPH Oxidase
transverse tubules
GAPDH
Ca2+ transients
RyR1
Cav1.1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00105/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00105/full

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