Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion

Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion

Tuberculosis (TB) presents a serious health problem with approximately one-third of the world’s population infected with Mycobacterium tuberculosis in a latent state. Experience from the pre-antibiotic era and more recent clinical studies have established a beneficial role of sunlight and vitamin D...

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Bibliographic Details
Main Authors: Anna K. O. Rode, Martin Kongsbak, Marie M. Hansen, Daniel Villalba Lopez, Trine B. Levring, Anders Woetmann, Niels Ødum, Charlotte M. Bonefeld, Carsten Geisler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
vitamin D
tuberculosis
T cells
dendritic cells
Th1
IFNγ
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00656/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00656/full

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