PPARγ Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19

Summary: The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections are poorly understood. To uncover these events, we performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment pattern similar to that of PPARγ-knockout macr...

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Bibliographic Details
Main Authors: Christophe Desterke, Ali G. Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308038