Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Abstract Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast diseases. However, litt...

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Bibliographic Details
Main Authors: Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Biology
Subjects:
Sfrp1 and Sfrp5
Hyperactivation
Canonical Wnt pathway
Trophoblast
Ascl2
Online Access:http://link.springer.com/article/10.1186/s12915-020-00883-4

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http://link.springer.com/article/10.1186/s12915-020-00883-4

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