Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis

Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis

Nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) is involved in fibrosis of multiple organs, such as kidney, liver, lung, and the like. However, the role of NLRP3 in cardiac fibrosis is still controversial and remains unclear. The study aims to investigate the role of NLRP3 on cardi...

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Bibliographic Details
Main Authors: Chen Liu, Tongtong Hu, Zhulan Cai, Qingwen Xie, Yuan Yuan, Ning Li, Saiyang Xie, Qi Yao, Jinhua Zhao, Qing Qing Wu, Qizhu Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nucleotide-binding oligomerization domain-like receptor 3
cardiac fibrosis
reactive oxygen species
high mobility group box 1 protein
heart failiure
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00713/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00713/full

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