Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling.

Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling.

Chronic nephrotoxicity of immunosuppressives is one of the main limiting factors in the long-term outcome of kidney transplants, leading to tissue fibrosis and ultimate organ failure. The cytokine TGF-β is considered a key factor in this process. In the human renal fibroblast cell line TK-173, the m...

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Bibliographic Details
Main Authors: Georg Kern, Sabine M Mair, Susie-Jane Noppert, Paul Jennings, Herbert Schramek, Michael Rudnicki, Gerhard A Mueller, Gert Mayer, Christian Koppelstaetter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4015940?pdf=render

Internet

http://europepmc.org/articles/PMC4015940?pdf=render

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