Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia

Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia

Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical (O2⋅_) promotes an acute post-asphyxial inflam...

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Bibliographic Details
Main Authors: Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neurology
Subjects:
asphyxia
carboxyfullerene
endothelium
inflammation
leukocytes
oxypurinol
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00447/full

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