Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and ventilator-induced lung injury (VILI). Autophagy is a key regulator of inflammasome activation in macrophages. Here, we investigated the role of autopha...

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Bibliographic Details
Main Authors: Nobuyuki Nosaka, Daisy Martinon, Debbie Moreira, Timothy R. Crother, Moshe Arditi, Kenichi Shimada
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
autophagy
inflammasome
IL-1β
lipopolysaccharide
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00207/full

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