Application of a pharmacokinetic model of metformin clearance in a population with acute myeloid leukemia

Application of a pharmacokinetic model of metformin clearance in a population with acute myeloid leukemia

Objective: We aimed to estimate the metformin-associated lactic acidosis (MALA) risk by assessing retrospectively the renal clearance variability and applying a pharmacokinetic (PK) model of metformin clearance in a population diagnosed with acute myeloid leukemia (AML) and diabetes mellitus (DM). M...

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Bibliographic Details
Main Authors: Alice C Ceacareanu, Geoffrey W Brown, Hoda A Moussa, Zachary A P. Wintrob
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Journal of Research in Pharmacy Practice
Subjects:
Acute leukemia
Metformin
Metformin-associated lactic acidosis
pharmacokinetics
Online Access:http://www.jrpp.net/article.asp?issn=2319-9644;year=2018;volume=7;issue=1;spage=41;epage=45;aulast=Ceacareanu

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http://www.jrpp.net/article.asp?issn=2319-9644;year=2018;volume=7;issue=1;spage=41;epage=45;aulast=Ceacareanu

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