Co-cultivation With 5-Azacytidine Induced New Metabolites From the Zoanthid-Derived Fungus Cochliobolus lunatus

Co-cultivation With 5-Azacytidine Induced New Metabolites From the Zoanthid-Derived Fungus Cochliobolus lunatus

The zoanthid-derived fungus Cochliobolus lunatus (TA26-46) has been proven to be a source of bioactive 14-membered resorcylic acid lactones (RALs). In the present study, chemical epigenetic manipulation was applied to this fungal strain with a DNA methyltransferase inhibitor resulting in the signifi...

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Bibliographic Details
Main Authors: Jing-Shuai Wu, Xiao-Hui Shi, Ya-Hui Zhang, Jia-Yin Yu, Xiu-Mei Fu, Xin Li, Kai-Xian Chen, Yue-Wei Guo, Chang-Lun Shao, Chang-Yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
chemical epigenetic manipulation
DNA methyltransferase inhibitor
Cochliobolus lunatus
α-pyrones
DP4+ probability calculation
the fragment molecules
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00763/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00763/full

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